D manosa en polvo a granel

¿Qué es D Mannose polvo a granel?

Polvo de D manosa es un monosacárido. Es un isómero de glucosa y entra en las células a través de proteínas de transporte de glucosa. La manosa es catcatalizada intracelularmente por la hexoquinasa para producir la manosa 6-fosfato (M6P), que puede ser catpor la fosfomanosa isomerasa (PMI) para entrar en la vía glucolítica o por la fosfomanosa mutasa (PMM2) para entrar en la vía de glicosilación.

La D manosa está presente en un estado libre en la cáscara de ciertas plantas, como en la cáscara de los cítricos, pequeñas cantidades de manosa libre en frutas como melocotones y manzanas, y glicanos que contienen d-manosa en semillas de palma de marfil, levadura, algas rojas, globulina de suero, mucina parecida a un huevo, y Mycobacterium tuberculosis.

Green Spring Technologies produce D Mannose Powder Bulk Con alta pureza, bajo contenido de endotoxinas, bajos contede colonias y bajos metales pesados. Se prueba para metales pesados como se especifica en ICH Q3D en concentraciones tan bajas como partes por bill(PPB).

Green Spring tiene un excelente equipo de i + d, un experimentado equipo de producción y un equipo de ventas profesional. Tenemos un sistema de gestión de calidad sistemática y organizar la producción en estricto acuerdo con ISO, HACCP, y otras normas de calidad. Hemos aprobado Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, y muchas otras certificaciones. Podemos proporcionar informes de prueba autorizados de terceros.

Especificaciones: 

Normativa:

Se ajusta a la normativa de la UE.

Benefits:

Inhibiting Tumour Growth

A study reported in Nature 2018 found that D mannose powder can inhibit tumour growth by suppressing glucose metabolism by screening the effects of different hexoses on the growth of tumour cell lines. Lui Lei's team sought to explore whether various hexoses affect tumour immunity. Through screening, the researchers found that high concentrations of D-mannose were able to degrade PD-L1 protein in TNBC cells. In-depth mechanistic studies revealed that D-mannose treatment could promote the activation of AMPK, which promoted the phosphorylation of the S195 site of PD-L1 protein. The phosphorylation of this site can weaken the glycosylation of PD-L1 protein, which leads to the degradation of PD-L1 protein through proteasome.

Further studies revealed that D-mannose-mediated degradation of PD-L1 also inhibited the DNA damage repair process in tumour cells, resulting in a facilitating effect on radiotherapy for TNBC. In a mouse model of TNBC, the combination of oral D mannose and PD-1 antibody treatment significantly prolonged the survival of hormonal mice and increased CD8+ T cell infiltration and granzyme B expression in the tumour. Similarly, the combination of oral D-mannose and ionising radiation significantly inhibited tumour growth in vivo and significantly enhanced the efficacy of radiotherapy in TNBC mice.

In conclusion, this study revealed a new function of D-mannose - degradation of PD-L1 protein and reported for the first time the facilitating effect of D-mannose on immunotherapy and radiotherapy of TNBC, which provides a new strategy for the clinical treatment of TNBC.

Cell Recognition

D Mannose powder is one of the important components of cell surface glycosylation that can participate in cell recognition and interaction with the external environment.

Immunomodulation

D Mannose plays an important role in the immune system and is involved in intercellular signaling, inflammatory regulation, and activation of immune cells.

Antiviral

D mannose powder can interact with certain viral structural proteins to inhibit viral invasion and replication processes.

Applications:

For Feed Product：

Overuse of antibiotics in farming leads to the proliferation of resistant bacteria as well as pollution of the environment. Studies have demonstrated that D mannose powder can inhibit the infection of Salmonella in young chickens without side effects. Adding D mannose powder to livestock and poultry feed has the effect of inhibiting the proliferation of pathogens in the intestinal tract, protecting the health of animal intestinal tract, increasing immunity and disease resistance, and improving feed utilization.

For Health Products:

D Mannose powder has been used clinically as a glyconutrient. It can be widely distributed in body fluids and tissues, especially in the nerves, skin, testes, retina, liver, and intestine. The body can directly use mannose to synthesize glycoproteins and participate in immune regulation. In recent years, a series of surprising physiological activities of mannose, a common monosaccharide, have been revealed, including anti-inflammation, inhibition of bacterial infections, alleviation of diabetes, anti-tumor, etc. D mannose powder has been used as an additive in nutraceuticals.