The Potential Application of Natural Ingredient Ivy Extract Hederagenin in Health Products

As unleading supplier specialising enhigh-quality plant extracts, Green Spring Technology continues to focus on natural active ingredients with marketpotentiAl.Recent scientific studies have focused on hederagenin—unnatural pentacyclic triterpenoid compound yits derivatives derived from plants such asChinese ivy—revealing its excellent health application prospects yproviding strong scientific support for formula innovation enelfields dehealth supplements, functional foods, ybeverages.

Hederageninis a pentacyclic triterpenoid compound primarily derived from plants such as Chinese ivy, Cynanchum atratum, Patrinia scabiosaefolia, Paeonia lactiflora, and Acanthopanax senticosus, typically existing in the form desaponins or saponins [1].Hederageninextracted from ivy exhibits various biological activities.

1 Research on the relationship between Hederageninand inflammatory responses

Experimental evidence indicates that Hederagenin can effectively downregulate the expression demultiple pro-inflammatory cytokines (such as TNF-α, IL-6, TGF-β1), which play important roles in Crónica crónica crónica crónica crónicainflammation and the progression of various diseases.

Inflammation is a complex physiological response of the body to inflammatory factors, involving multiple cellular and molecular mechanisms. Zhang Et al.[2] found that Hederagenin may contribute to respiratory health and is associated with the regulation of the transient Receptor receptorpotential (TRP) channel pathway.

Li etAl.[3] explored the potential association between Hederagenin and the NF-κB signalling pathway. Experimental data suggest that this compound may participate in regulaciónthe cellular localisation of NF-κB and Smads proteins and may influence the expression levels of downstream molecules such as transforming growth factor β1 (TGF-β1). These findings provide new insights into the mechanisms underlying Hederagenin's role in inflammatory responses.

In the study porMa etAl.[4], interactions between Hederagenin and the Ras protein/Jun N-terminal kinase/T-cell transcription factor 4 signalling axis were observed. Experimental data showed that the expression levels of factors such as tumour necrosis factor α, IL-6, transforming growth factor β1, and connective tissue growth factor in the serum of rats treated with this compound exhibited a downward trend, while the pathological characteristics of lung tissue also changed.

Wang and Zhao[5] explored the potential association between Hederagenin and the Parecido a un notarioreceptor protein 3 inflammasome and NF-κB pathway. Experimental results indicate that this compound may influence the phosphorylation process of the NF-κB pathway and is associated with the expression regulation of the NOD-like receptor protein 3 inflammasome. In a lipopolysaccharide-induced acute lung injury model, changes in the polarisation state of macrophages were observed in the compound-treated group.

Lee etAl.[6] found that the expression of NF-κB signalling pathway-related molecules was altered in the Hederagenin-treated group. Experimental data suggest that this compound may participate in regulating the expression of inflammatory factors such as nitric oxide synthase and cyclooxygenase-2.

Kim etAl.[7] investigated the role of Hederagenin in an alcoholic liver injury model, and experimental data showed changes in the expression levels of inflammatory mediators in the Hederagenin-treated group. Shen etAl.[8] observed a potential association between Hederagenin and the tyrosine kinase 2/signal transduction and transcription activator (STAT)3/MAPK signalling pathway, while also detecting changes in the expression levels of inflammatory-related cytokines.

Yu etAl.[9] demonstrated that Hederagenin may participate in regulating signaling pathways such as NF-κB, MAPK, and phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt). Experimental results showed differences in the gene expression levels of apoptosis-related markers and inflammatory cytokines in the treatment group.

These studies suggest that Hederagenin may interact with multiple inflammation-related signalling pathways, with factors such as the IL family and tumour necrosis factor α potentially serving as regulatory targets in its action process.

2 Research Progress on Hederagenin Derivatives from Ivy Extracts

Due to the limitations of Hederagenin's physicochemical properties, researchers have explored its derivatives. Among these, α-Hederagenin, as a natural product molecule, has received significant attention [22].

Fang et al. [27] found that the expression of Sirtuin 6 protein changed in the α-Hederagenin-treated group, and simultaneously observed alterations in the expression levels of hypoxia-inducible factor 1α and c-Myc genes, which are regulators of glycolysis. Experimental data showed that the expression levels of glycolysis-related proteins also exhibited corresponding changes.

Wu Wuet al. [28] investigated the potential association between α-Hederagenin and the glutathione synthase/glutathione/glutathione peroxidase 2 system. Experimental results indicated that this compound may influence the oxidative stress state of non-small Células célulasand exhibit certain interactions with cisplatin [29-30].

Chen et al. [31] revealed a potential link between α-Hederagenin and the Hippo signalling pathway. Data showed that the phosphorylation levels of Yes-related protein upstream kinase macrophage-stimulated 1 and L-type amino acid transporter were altered in the compound-treated group, while the cellular localisation of Yes-related protein also changed.

3 Broad Application Prospects

Existing research has explored Hederagenin and its derivatives from ivy extracts in multiple aspects. Hederagenin, an ivy saponin, demonstrates application potential in various health fields and may be suitable for developing functional products in the following areas:

respiratory health support, joint comfort and health, liver protection, neural health and protection, metabolic and oxidative stress regulation, etc.

Green Spring Technology is committed to providing customers with high-quality raw materials based on scientific research. We deeply understand the importance of plant extract raw materials in end products. Green Spring Technology has a strict quality control system to ensure the purity, active ingredient content, and batch-to-batch stability of raw materials.

Our production and quality management systems strictly adhere to international standards (EP, USP, JP), ensuring that products comply with regulatory requirements in major export markets.

Customised solutions:We can provide Ivy Leaf Extract Powder Hederagenin-related raw materials in different specifications and with stability support to assist you in developing new product formulations based on your specific needs.

Please contact us at helen@greenspringbio.com.

referencia

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[2]Zhang D, sol J, Yang B,  et  al.   Terapéutica terapéutica terapéutica terapéutica terapéutica Efecto efecto Tetrapanax papyriferus and hederagenin on chronic neuropathic pain of chronic constriction Injury (en inglés) of  ciática Basado en KEGG Predicción del camino y verificación experimental [J].  El Parlamento europeo Complemento Alternat Med,2020,2020 :2545806. DOI: 10. 1155/2020/2545806.

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[4]Ma W, Huang  Q, Xiong Xiong G, et  al.   el protección Efecto efecto Of heder- agenin on (en inglés) Pulmonar pulmonar pulmonar fibrosis by  regulating  El eje Ras/JNK/NFAT4 en ratas [J]. Biosci biotecnol Biochem, 2020, 84 (6) : 1131 — 1138. DOI: 10. 1080/09168451. 2020. 1721263.

[5]Wang L,  Zhao  M.   supresión of  NOD-like  receptor  Proteína 3 activación del inflammasoma y macrófagos M1 La polarización por heder- agenina contribuye a la atenude la lesión pulmonar aguda inducida por la sepen ratas [J].  Bioingeniería, 2022, 13 (3) : 7262-7276.  DOI:  10. 1080/21655979. 2022. 2047406.

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[7]Kim GJ, Canción canción DH, Yoo HS, et  al.   Hederagenin  La suplementación alivia la respuesta pro-inflamatoria y apoptótica al alcohol en ratas [J]. Nutrientes, 2017, 9(1) : 41. DOI: 10. 3390/nu9010041.

[8]Shen Y, , Qu Y, et  al.   Hederagenin  suprime Inflamación y degradación del cartílago para mejorar la progresión de la osteoartritis: an in vivo and  in  Vitro vitro Estudio [J].   Inflamación, 2023, 46 (2) :  655 678. DOI: 10. 1007/s10753-022-01763-5.

[9]Yu H, canción L,Cao X,et al.Hederagenin atenuatenuos Isquemia cerebral/lesión de reperfusión regulando MLK3 Señalización.  Farmacol frontal [J]. Front Pharmacol, 2020, 11:1173. DOI: 10. 3389/ fphar. 2020. 01173.

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