¿Qué ingrediente activo contiene el extracto de valeriana?

Currently, there are few reviews or summaries of research on the chemical composition and physiological activities of Valeriana officinalis. This paper aims to organize and analyze recent domestic and international research progress on Valeriana officinalis, providing a reference basis for future studies on its chemical composition, physiological activities, and comprehensive development. Valerian (Valeriana officinalis L.) is the dried root and rhizome of the plant Valeriana officinalis L., belonging to the Valerianaceae family [1]. It has a cold nature, a pungent and bitter taste, and enters the heart and liver meridians. This herb has sedative, anxiolytic, and antispasmodic effects. Clinically, it is primarily used to treat insomnia, palpitations, anxiety, and other conditions associated with nervous system disorders, as well as for anxiety relief and the treatment of gastrointestinal pain [2-3]. It is widely distributed in northwestern and southwestern regions of China, including Chang'an, Ningxian, Lantian y Huanglong en la provincia de Shaanxi.

1 Morfoe identificación

Valerian is a perennial herbaceous plant belonging to the Valerianaceae family. It has a thick and short rhizome, fleshy, with numerous fibrous roots that are elongated and branched, and emits a strong aromatic odor. The stem is erect, 50–100 cm tall, cylindrical with multiple purple longitudinal ridges, the nodes slightly protruding, and covered with white hairs. The basal leaves are pinnately deeply lobed. They have long petioles, which wither early or remain as remnants; stem leaves are opposite, odd-pinnately lobed, with 3–15 lobes, the margins having irregular coarse teeth or entire, both surfaces sparsely covered with white short hairs, the veins sunken and convex, the leaf bases flattened and broad, slightly clasping the stem. Flowers bloom in spring and summer, forming dense corymbose inflorescences; bracts are linear, opposite at the base of the flower axis, covered with white short hairs; calyx inconspicuous; corolla tubular, 5-lobed at the apex, white with a red halo, the red halo particularly prominent on the corolla tube; 3stamens; 1 pistil, stigma extending beyond the corolla. Achenes narrow, elongated, and flattened, with a feathery crown at the apex.

V. officinalis L. (V. officinalis L.) es una hierba medicinal registrada por primera vez en *Scientific Folk Herbs*, también conocida como "small Rescue," "large Rescue," "ground clinging Tiger," y "seven-mile Fragrance" (*Shaanxi Herbal Medicine*). En *Natural Medicinal Plants of the Qinling and Ba Mountains*, its authentic name is “small rescue,” and its commonly used parts are the root and rhizome [4]. Based on the source of the medicinal plant, it is also recorded in *Chinese Materia Medica* and *Comprehensive Dictionary of Chinese Herbal Medicines*. Due to its primary distribution in Shaanxi Province and its extensive coverage, “V. officinalis” serves as the original plant source for medicinal V. officinalis in Shaanxi, making it the primary medicinal variety.

2 componentes activos del extracto de V. officinalis

Extracto de valerianaContiene principalmente componentes volátiles de aceite (monoterpenos y sesquiterpenos), con las raíces que contienen niveles más altos de cicloartenol y sesquiterpenos, y las raíces que tienen un mayor contenido de aceites volátiles [5].

2.1 monoterpenos y sesquiterpenos

Volatile oils are important compounds in the roots and rhizomes of medicinal Valeriana, with specified minimum content requirements in the European Pharmacopoeia. Michael et al. [6] confirmed the presence of oil droplets in both the external and internal regions of Valeriana roots through histological techniques, optical microscopy, and Fourier transform infrared spectroscopy in preliminary experiments. Based on this, fluorescence microscopy was subsequently used to analyze images of the entire root cross-section, revealing a large number of oil droplets (averaging 43% of total oil droplets) located near the root surface. The remaining oil droplets were found in the internal regions (parenchymatous tissue), and their density showed a gradient from the internal to external regions depending on genotype, root thickness, and harvest depth.

La actividad farmacológica se concentra principalmente en monoterpenos, cuyos componentes químicos incluyen principalmente borneol, acetato de isoborneol y acetato de borneol; Los sesquiterpenos están presentes en cantidades relativamente menores, principalmente en los tipos valerianano y guaiacolano [7].

Wang et al. [8 —9] isolated two new guaiane-type sesquiterpenoids from the roots of Valeriana: valerol A (1) and kessyl 3-acetate (2); and five known compounds: valer-acetate (3), anismol A (4), orientalol C (5), spatulenol (6), and 4α,10— —epoxyaromade-ndrane (7). Additionally, Volvalerenone A (8) was first isolated from Valeriana officinalis, marking the first discovery of a novel tricyclic terpenoid compound with a 5/6/6 ring system. The structural formulas of the components are shown in Figure 1. A total of 34 cycloaromatic terpenoids have been isolated from Valeriana officinalis, including 26 aglycones and 8 glycosides. Most of the triterpenoid glycoside aglycones are triterpenoid triterpenoids (also known as valerian triterpenoids or valerian glycosides), with most glycosides formed by the condensation of the hydroxyl group at the C-11 position with the hydroxyl group at the glucose terminal. The molecular structure contains Δ3(4), Δ5(6) [not Δ7(8)], and a three-membered oxygen-containing ring between C-8 and C-10. Substituents are primarily located at the C-1, C-7, and C-11 positions. The triterpenoids in Valeriana can be further classified into four categories: mono-ene closed-ring, polyene, diene closed-ring, and diene open-ring [10], with their parent nuclei shown in Figure 2.

Triterpenoides 2.2

Jiang Xia et al. [11] aislaron tetrahidrotriterpenoides de Valeriana: − -sitosterol, andÁcido ursóácidoEs un triterpenoide del tipo ácido ursólico.

2.3 fenilpropanoides

En los últimos años, los compuestos fenilpropanoides aislados de Valeriana incluyen fenilpropanoides y lignanos, en su mayoría de los tipos de monoxepano y dioxepano. Zuo Yue-ming et al. puriseis compuestos fenilpropanoides utilizando varios métodos de cromatode columna. Britta et al. estudiaron el contenido de lignanos en elmethanol extract of Valeriana root and isolated eight lignan compounds. See Tables 1 and 2.

Cuadro 1 Compuestos de fenilpropano

Cuadro 2 Compuestos de lignina

2.4 flavonoides

La valeriana también contiene componentes químicos flavonoides, que se encuentran principalmente en las partes superiores de la planta. El contenido de flavonoen las flores y frutos generalmente excede al de las hojas. Zuo et al. aislado y puriflavonode valeriana usando varios métodos cromatográficos, identificando lo siguienteCompuestos flavonoides. Véase el cuadro 3.

Cuadro 3 Compuestos flavonoides

2.5 alcaloides

The alkaloids present in Valeriana plants are primarily found in the underground parts of the plant, with a content of approximately 1%. Approximately 19 alkaloids have been isolated from Valeriana, primarily classified into two types: monoterpenoid and apioid. Monoterpenoids include pyridine-type (valeroline, valeranine) and quaternary ammonium-type. Alkaloids in Valeriana are present in low concentrations, and recent reports on the isolation of alkaloids from Valeriana are limited. It is currently believed that the total alkaloids have antibacterial activity, and the roots contain alkaloids such as β-valerine, 8-methoxyactinidine, chatinine, actinidine, isovaleramide, valeriamine, and valeriane [19].

3  Actividad fisiológica

3.1 efectos sobre el sistema nervioso

sedantes

Sung et al. [20] reported that Valeriana contains valerian diol and valerian triterpenes. Among these, valerian diol can reduce the excitability of reflexes and smooth muscle spasms, thereby effectively inhibiting the cerebral cortex, making it the active component responsible for Valeriana's efecto sedante. Los triterpenvalerianos muestran una mayor actividad sedante. Hyeon et al. [21] investigaron los efectos beneficiosos de las mezclas de Valeriana/ cascada en el sueño en un modelo animal de mamíferos. En un modelo de sueño inducido por pentobarbital, las mezclas de Valeriana, cascada y Valeriana/ cascada redujeron significativamente la latencia al sueño y aumentaron efectivamente el tiempo total de sueño en comparación con el grupo de control. Taavoni et al. [22] seleccioncomo sujetos a mujeres de 50 a 60 años. Las comparaciones entre el grupo experimental y el grupo placebo indicaron que la valeriana efectivamente mejoró los síntomas del trastorno del sueño en mujeres perimenopáusicas. Huang Huabin et al. [23] informaron que la valeriana puede tratar eficazmente el insomnio primario. Este estudio investigó los efectos de la valeriana en los niveles plasmáticos de melatonina (tm) e insomprimario, encontrando que sus efectos terapéuticos estaban aproximadamente asociados con un aumento en los niveles plasmáticos de melatonina.

3.1.2 efectos antiespasmódicos y analgésicos

Parvaneh et al. [24] selecciona 100 estudiantes mujeres como sujetos para investigar si la valeriana podría tratar efectivamente la dismenorrea. El experimento se llevó a cabo utilizando un diseño doble ciego al inicio y durante el período de intervención, con evaluaciones basadas en criterios de puntuación simulados observados. Al registrar la gravedad del dolor y las manifestaciones físicas de los sujetos, se concluyó que la valeriana puede tener efectos antiespasmódicos. Dado que inhiefectivamente las contracciones uterinas en los sujetos, esto demostró aún más queLa valeriana tiene un efecto terapéuticoSobre dismenorrea en mujeres.

3.1.3 antidepresivos

The volatile oil components in Valerian, including Valerianol and Valerianic acid ester, exhibit significant antidepressant activity. Pakseresht et al. [25] found that Valerian has certain antidepressant and anxiolytic effects. Zhao Lihui et al. [26] found that valerian water extracts and alcohol extracts exhibit antidepressant effects. Yan Shuo [27] synthesized a valerian compound formulation with antidepressant properties. By observing the specific manifestations of experimental animals during the experiment, it was found that the valerian compound formulation significantly alleviated depression in experimental animals with few adverse reactions.

3.1.4 efectos ansiolíticos y antiepilépticos

Valerian root extract exhibits anti-anxiety effects. Wang Yanli et al. [28] found that valerian root extract exerts anti-anxiety effects by regulating the function of the hypothalamic-pituitary-adrenal (HPA) axis. Del et al. [29] used zebrafish as experimental subjects and concluded that valerian acid possesses anti-anxiety effects. The mechanism lies in valerian's interacción selectiva con los receptores metabólicos de glutamato I y II. Murphy et al. [30] encontraron que valerian's los efectos ansiolíticos pueden ser potencia través de receptores GABA exógenos, y el ácido valerénico es el principal componente responsable de valerian's reducción significativa en el comportamiento de ansiedad en ratones. Wu Bo et al. [31] encontraron que los componentes volátiles del aceite en la valeriana actúan sobre el equilibrio entre aminoácidos excitatorios e inhibidores en el cerebro de ratas modelo, ejerciendo así un efecto antiepiléptico.

3.1.5 efectos anticonvulsivos, protectores cardiovasculares y antitumorales

Mohammad et al. [32] evaluated the effects of Valeriana extract on temporal lobe epilepsy in rats and concluded that it exhibits anticonvulsant effects. Yang Shuhong et al. [33] reported that Valerian extract, when administered as a pretreatment, can protect rat myocardial cells from ischemia-reperfusion injury. Liu Junfeng et al. [34] reported that the volatile components in Valerian have antiarrhythmic effects. The mechanism may involve an unknown component entering the serum in its original form and acting as a serum drug component with antiarrhythmic properties. In vivo experiments using S180 or EAC tumor models in mice, valerian cycloartane terpenoid esters exhibited significant antitumor effects against S180 (solid type) and significantly prolonged the survival time of EAC-induced ascites cancer mice [35].

3.2 efectos antimicrobianos y antivirales

Wang et al. [36] lo encontraronAceite esencial de valerianaPresenta actividad antimicrobiana de amplio espectro, con valores de concentración mínima inhibit(MIC) que varían ampliamente de 62,5 μg/mL a 400 μg/mL, y los valores de IC₅₀ oscilaron de 36,93 μg/mL a 374,72 μg/mL. También mostró una moderada actividad antifúncontra el crecimiento de Candida albicans e inhibió la germinde las esporas de Magnaporthe oryzae. Los experimentos In vitro indicaron que los componentes valerianos pueden ser los componentes activos responsables de su actividad antiviral, lo que confiere a la valeriana actividad anti-rotavirus.

3.3 efectos hepatoprotectores y nefroprotectores

Xu Shali et al. [37] found in a Wistar rat model of liver damage induced by a high-cholesterol, high-fat, and high-sugar diet that Valeriana extract increased total bile acid (TBA) content in bile, improved the TBA/total cholesterol (TC) ratio, reduced serum TBA concentration, and significantly alleviated liver damage. Chen Ling et al. [38] found that Valerian oil effectively improved kidney damage in type 2 diabetic rats, reduced proteinuria, and delayed kidney function damage. Their effects were associated with lipid-lowering, antioxidant properties, and inhibition of protein kinase C (PKC) activation in the renal cortex.

Otros efectos

Valerian has antioxidant properties, In a study comparing the free radical scavenging activity, reducing capacity, and total antioxidant activity of its extracts, the highest and lowest activities were observed in water and acetone extracts. The 80% methanol extract exhibited the highest activity in reducing capacity and free radical scavenging activity measurements [39]. Sung et al. [20] reported that Valeriana root extract and Valerian acid enhance cognitive function in aged mice. Dorian et al. [40] aimed to assess whether the standardized extract (SE) of Valeriana officinalis has muscle relaxant effects by reducing skeletal muscle strength and/or neuromuscular tension in mice. This study provided evidence supporting the muscle relaxant effects of Valeriana officinalis extract on skeletal muscle.

4 aplicaciones como espe.

Valerian has also found widespread application in daily life, primarily in tobacco and food products. Valerian essential oil, derived from its roots and rhizomes, is a key ingredient in the formulation of high-quality tobacco flavorings and is widely used in the tobacco industry as an important spice. Valerian serves as an excellent raw material for essential oil production and is extensively utilized in food products, as well as a valuable perfume and fragrance ingredient in the perfume industry. Valerian essential oil, prepared through processing, is easy to manufacture with simple equipment, a straightforward production process, and is easy to operate and process [41].

5 conclusión

Valerian contains a large number of active components and exhibits diverse pharmacological effects, which has attracted increasing attention from researchers studying its pharmacological activities. These studies are primarily divided into two aspects: first, as a traditional medicinal plant, valerian contains a wealth of chemical components. By summarizing and organizing relevant literature from recent years, the latest isolated single compounds have been identified, with volatile oil components and cycloartenol derivatives being the most frequently reported. while reports on alkaloids are relatively scarce. In the isolation of single compounds, research has primarily focused on specific extraction sites rather than systematic isolation from all parts. The omission of certain extraction sites may result in an incomplete characterization of their components. The other aspect is the study of physiological activities, with recent years seeing more in-depth research on pharmacological mechanisms, primarily concentrated on the nervous system, antibacterial effects, and liver protection. However, studies on the activity and mechanisms of single compounds isolated from Valeriana are limited, primarily focusing on crude extracts. The physiological activities of some single compounds remain unclear, and the material basis for their pharmacological activities has not been clearly elucidated. Further research is needed to strengthen the study of single active components and their mechanisms.

Additionally, Valeriana officinalis is commonly used as a spice in the tobacco and food industries, primarily as a health supplement and flavoring agent. However, there are few research-based formulations developed from Valeriana officinalis. Therefore, it is essential to conduct comprehensive research on the active components and pharmacological effects of Valeriana officinalis, and based on this, develop effective formulations to uncover its potential market value. The medicinal value and special applications of Valeriana officinalis require further investigation.

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